Edenhofer Lab

Genomics, Stem Cell Biology and Regenerative Medicine

Research Interests

We develop and employ cellular reprogramming to comprehensively analyze human diseases at molecular and cellular level paving the way for novel therapeutic approaches. Our focus is on neurodevelopmental disorders, neurodegeneration and cardiovascular disease. We were able to show for the first time direct conversion of skin cells into multipotent neural stem cells, designated as iNSC (induced neural stem cells). Though artificially induced, iNSCs do not differ from their counterparts derived either from pluripotent stem cells or primary tissue. Employing iNSCs we simulate the development of the human nervous system in the culture dish and analyze regeneration and repair mechanisms of the brain. Studying diseases, such as Parkinson’s Disease, Alzheimer’s Disease, Multiple Sclerosis and Spinal Cord Injury, with iNSCs will help us to develop novel therapeutic interventions and eventually result in stem cell-based autologous cell replacement therapies.

Picture of Professor Frank Edenhofer, PhD. Head of the Edenhofer Laboratory

Ongoing research

From patient samples, to in vitro disease models, all the way to novel therapeutic approaches. This figure gives an overview
of the pipeline of cellular reprogramming, direct conversion and disease modeling applied in our lab.
Click on the illustration to learn more about our ongoing projects in detail.

From patient samples, to in vitro disease models, all the way to novel therapeutic approaches. This figure gives an overview of the pipeline of cellular reprogramming, direct conversion and disease modeling applied in our lab. Click on the illustration to learn more about our ongoing projects in detail.

Recent News

28.03.23:
We had a great time at the SY-STEM 2022 meeting in Vienna. Lots of inspiring talks!

21.03.23:
The Edenhofer lab will is looking forward to participate at the SY-STEM 2022 meeting in Vienna. Come check out our posters!